Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia

被引:62
作者
Dechend, R
Homuth, V
Wallukat, G
Müller, DN
Krause, M
Dudenhauseu, J
Haller, H
Luft, FC
机构
[1] Helios Clin, Charite, HELIOS Klinikum, Fac Med, Berlin, Germany
[2] Dept Obstet, Berlin, Germany
[3] Max Delbruck Ctr Mol Med, Berlin, Germany
[4] Hannover Med Sch, Dept Nephrol, Hannover, Germany
关键词
preeclampsia; angiotensin; agonistic autoantibodies; tissue factor; reactive oxygen species;
D O I
10.1016/j.jsgi.2005.11.006
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Immune mechanisms and circulatimg mediators may be important in the pathogenesis of preeclampsia. We review our findings on agonistic antibodies against the angotensin II (Ang II) receptor (AT1-AA) and their possible role in file pathogenesis of this disorder. AT1-AA appear in the course of precclampsia and are largely gone by 6 weeks after delivery. AT1-AA detection relies on a bioassay using spontaneously beating neonatal rat cardiomyocytes. Their specificity has been documented by other methods, including Western blotting co-localization, and co-localization and co-immunoprecipitation experiments. AT1-AA induce signaling in vascular cells and trophoblasts including transcription factor activation. The signaling results in tissue factor production and reactive oxygen species generation, both of which have beem implicated in preeclampsia. The role of AT1-AA in precclampsia and other severe hypermisive conditions has not yet been proved with certainty. However, we believe the findings are compelling and warrant further study. (J Soc Gynecol Investig 2006; 13:79-86) Copyright (c) 2006 by the Society for Gynecolgic Investigation.
引用
收藏
页码:79 / 86
页数:8
相关论文
共 55 条
[1]   Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness [J].
AbdAlla, S ;
Lother, H ;
el Massiery, A ;
Quitterer, U .
NATURE MEDICINE, 2001, 7 (09) :1003-1009
[2]  
ACOG Committee on Obstetric Practice, 2002, Int J Gynaecol Obstet, V77, P67
[3]   THE EFFECT OF ANGIOTENSIN-II ON PLATELET INTRACELLULAR FREE CALCIUM-CONCENTRATION IN HUMAN-PREGNANCY [J].
BAKER, PN ;
KILBY, MD ;
PIPKIN, FB .
JOURNAL OF HYPERTENSION, 1992, 10 (01) :55-60
[4]   EFFECT OF LOW-DOSE ASPIRIN ON FETAL AND MATERNAL GENERATION OF THROMBOXANE BY PLATELETS IN WOMEN AT RISK FOR PREGNANCY-INDUCED HYPERTENSION [J].
BENIGNI, A ;
GREGORINI, G ;
FRUSCA, T ;
CHIABRANDO, C ;
BALLERINI, S ;
VALCAMONICO, A ;
ORISIO, S ;
PICCINELLI, A ;
PINCIROLI, V ;
FANELLI, R ;
GASTALDI, A ;
REMUZZI, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (06) :357-362
[5]  
Bohlender J, 2000, J AM SOC NEPHROL, V11, P2056, DOI 10.1681/ASN.V11112056
[6]  
Borghi C, 2002, J HYPERTENS, V20, pS52
[7]   Inhibition of TGF-β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies [J].
Caniggia, I ;
Grisaru-Gravnosky, S ;
Kuliszewsky, M ;
Post, M ;
Lye, SJ .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (12) :1641-1650
[8]   Role of tissue factor in embryonic blood vessel development [J].
Carmeliet, P ;
Mackman, N ;
Moons, L ;
Luther, T ;
Gressens, P ;
VanVlaenderen, I ;
Demunck, H ;
Kasper, M ;
Breier, G ;
Evrard, P ;
Muller, M ;
Risau, W ;
Edgington, T ;
Collen, D .
NATURE, 1996, 383 (6595) :73-75
[9]   Evidence of endothelial activation and endothelial activators in cord blood of infants of preeclamptic women [J].
Davidge, ST ;
Signorella, AP ;
Lykins, DL ;
Gilmour, CH ;
Roberts, JM .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1996, 175 (05) :1301-1306
[10]   Increased expression of cardiac angiotensin II type 1 (AT1) receptors decreases myocardial microvessel density after experimental myocardial infarction [J].
de Boer, RA ;
Pinto, YM ;
Suurmeijer, AJH ;
Pokharel, S ;
Scholtens, E ;
Humler, M ;
Saavedra, JM ;
Boomsma, F ;
van Gilst, WH ;
van Veldhuisen, DJ .
CARDIOVASCULAR RESEARCH, 2003, 57 (02) :434-442