Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men

被引:170
作者
Tangrea, J
Helzlsouer, K
Pietinen, P
Taylor, P
Hollis, B
Virtamo, J
Albanes, D
机构
[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, BALTIMORE, MD USA
[2] NATL PUBL HLTH INST, HELSINKI, FINLAND
[3] MED UNIV S CAROLINA, CHARLESTON, SC 29425 USA
关键词
25-hydroxyvitamin D; colorectal cancer; Finland; men; rectal cancer; vitamin D;
D O I
10.1023/A:1018450531136
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Experimental and human epidemiologic data suggest a protective role for vitamin D in large bowel cancer. To investigate this association, we conducted a nested case-control study within a Finnish clinical trial cohort. Cases (n = 146) were participants diagnosed with primary adenocarcinoma of the large bowel. Controls were matched (2:1) to cases on age, date of baseline blood draw, and study clinic. Prediagnostic serum levels of the vitamin D metabolites, 25-hydroxyvitamin D (25-OH D), and 1,25-dihydroxyvitamin D (1,25-DIOH D) were used as primary exposure measures. The baseline geometric-mean serum level of 25-OH D was 11.6 percent lower in cases than in controls (12.2 cf 13.8 ug/l, P = 0.01) while serum levels of 1,25-DIOH D did not differ by case-control status. No association was seen between serum levels of 1,25-DIOH D and large bowel cancer risk. However, the estimated relative risk (RR) of large bowel cancer decreased with increasing level of serum 25-OH D and the association was more pronounced for rectal cancer (55 cases; RR by quartile = 1.00, 0.93, 0.77, 0.37; trend P = 0.06). Neither exclusion of early cases nor multivariate adjustment for potential confounders materially altered these estimates. There was no evidence of effect modification by level of 1,25-dihydroxyvitamin D or with other known risk-factors for large bowel cancer.
引用
收藏
页码:615 / 625
页数:11
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