Potassium currents in periglomerular cells of frog olfactory bulb in vitro

被引:14
作者
Bardoni, R [1 ]
Puopolo, M [1 ]
Magherini, PC [1 ]
Belluzzi, O [1 ]
机构
[1] DIPARTIMENTO SCI BIOCHIM,I-41100 MODENA,ITALY
关键词
potassium current; olfactory bulb slices; patch-clamp; interneurones;
D O I
10.1016/0304-3940(96)12677-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Voltage-activated currents have been recorded from periglomerular cells in thin slices of frog olfactory bulb. Cells were examined with whole-cell patch clamp methods. The voltage-dependent potassium currents were studied after pharmacological block of inward currents. Depolarising steps from -130 mV gave an early transient, A-type, outward current and a delayed rectifier K+ current (I-KV) The two currents could be isolated on the basis of the differences in their kinetic properties. The A-current developed following a third-order kinetics when the membrane was depolarised to potentials more positive than -40 mV after preconditioning to potentials more negative than -60 mV. Once activated (tau(a) 2.5 ms at 0 mV), I-A inactivated following a single exponential (tau(ha) about 60 ms). I-KV activated with a second-order kinetics above -30 mV with a time constant of 4 ms at 0 mV. I-A and I-KV Were sensitive, respectively, to 4-aminopyridine (4-AP) and tetraethylammonium (TEA).
引用
收藏
页码:95 / 98
页数:4
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