Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease

被引：26

作者：

Svedberg, Marie M. ^{[1
,2
]}

Rahman, Obaidur ^{[3
]}

Hall, Hakan ^{[1
,2
]}

机构：

[1] Uppsala Univ, Dept Med Chem, Preclin PET Platform, SE-75183 Uppsala, Sweden

[2] Uppsala Univ, Dept Publ Hlth & Caring Sci, SE-75183 Uppsala, Sweden

[3] Oslo Univ Hosp, Norwegian Med Cyclotron Ctr, Oslo, Norway

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2012年 / 39卷 / 04期

关键词：

Alzheimer's disease; Amyloid plaques; Molecular imaging; Positron emission tomography; Preclinical evaluation; POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; PITTSBURGH COMPOUND-B; PET IMAGING AGENTS; TRANSGENIC ANIMAL-MODELS; THIOFLAVIN-T-BINDING; IN-VIVO DETECTION; MOUSE MODEL; MONOCLONAL-ANTIBODY; STILBENE DERIVATIVES;

D O I：

10.1016/j.nucmedbio.2011.10.007

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Visualizing the neuropathological hallmarks amyloid plaques and neurofibrillary tangles of Alzheimer's disease in vivo using positron emission tomography (PET) or single photon emission computed tomography will be of great value in diagnosing the individual patient and will also help in our understanding of the disease. The successful introduction of [C-11]PIB as a PET tracer for the amyloid plaques less than 10 years ago started an intensive research, and numerous new compounds for use in molecular imaging of the amyloid plaques have been developed. The candidates are based on dyes like thioflavin T, Congo red and chrysamine G, but also on other types such as benzoxazoles, curcumin and stilbenes. In the present review, we present methods of the radiochemistry and preclinical evaluation as well as the main properties of some of these compounds. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：484 / 501

页数：18

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