A direct in vivo approach for skin gene therapy

被引：16

作者：

Vogel, JC ^{[1
]}

机构：

[1] NCI, NIH, Dermatol Branch, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS | 1999年 / 111卷 / 03期

关键词：

cytokines; DNA vaccination; epidermis; genetic immunization; keratinocytes; plasmid DNA;

D O I：

10.1046/j.1525-1381.1999.99223.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vivo gene therapy is a direct and effective way to express genes in the epidermis. Plasmid DNA that contains the desired gene can be injected intradermally, and it is rapidly absorbed and expressed by the epidermis. Because gene expression following plasmid injection is transient, the two principal therapeutic uses of this approach are genetic immunization and the expression of biological response modifiers to treat skin disease.

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收藏

页码：190 / 197

页数：8

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