5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats

被引：37

作者：

Cervo, L ^{[1
]}

Pozzi, L ^{[1
]}

Samanin, R ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI,I-20157 MILAN,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1996年 / 55卷 / 01期

关键词：

cocaine; conditioned place preference; 5-HT3 receptor antagonists; MDL; 72222; tropisetron; ondansetron; rat;

D O I：

10.1016/0091-3057(96)00046-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Three 5-HT3 receptor antagonists, MDL 72222, tropisetron, and ondansetron were studied for their ability to modify the conditioned place preference (CPP) induced by 10 mg/kg IP cocaine in rats. MDL 72222 (0.03-3 mg/kg SC) and tropisetron (0.01-0.1 mg/kg SC) administered, respectively, 30 min and 1 h before each conditioning session, did not affect the acquisition of cocaine CPP. Ondansetron (0.01-0.1 mg/kg SC) administered 30 min before each conditioning session or just before testing likewise had no effect. At 0.1 mg/kg SC ondansetron did not modify the increase of extracellular dopamine caused by 10 mg/kg cocaine in the nucleus accumbens. The results suggest that 5-HT3 receptor antagonists have no effect on the rewarding properties of cocaine or on the behaviour elicited by the stimuli previously associated with the drug's action.

引用

页码：33 / 37

页数：5

共 26 条

[1] 5-HT3 RECEPTOR ANTAGONISTS FAIL TO BLOCK THE SUPPRESSANT EFFECT OF COCAINE ON THE FIRING RATE OF A10 DOPAMINE NEURONS IN THE RAT [J].