Curcumin and Genistein Coloaded Nanostructured Lipid Carriers: in Vitro Digestion and Antiprostate Cancer Activity

被引：202

作者：

Aditya, N. P. ^{[1
]}

Shim, Myeongkuk ^{[2
]}

Lee, Inae ^{[1
]}

Lee, YoungJoo ^{[2
]}

Im, Moo-Hyeog ^{[3
]}

Ko, Sanghoon ^{[1
]}

机构：

[1] Sejong Univ, Dept Food Sci & Technol, Seoul 143747, South Korea

[2] Sejong Univ, Dept Biosci & Biotechnol, Seoul 143747, South Korea

[3] Korea Food & Drug Adm, Food Safety Bur, Food Stand Dept, Food Stand Div, Cheongwon Gun 363951, Chungcheongbukd, South Korea

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2013年 / 61卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

curcumin; genistein; nanostructured lipid carriers; prostate cancer; NANOPARTICLES; STABILITY; DELIVERY; ISOFLAVONES; ABSORPTION; DROPLETS; BEHAVIOR; PROTEIN; IMPACT; SOY;

D O I：

10.1021/jf305143k

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

To increase the oral bioavailability of curcumin and genistein, we fabricated nanostructured lipid carriers (NLCs), and the impact of these carriers on bioaccessibility of curcumin and genistein was studied. Entrapment efficiency was more than 75% for curcumin and/or genistein-loaded NLCs. Solubility of curcumin and/or genistein in simulated intestinal medium (SIM) was >75% after encapsulating within NLCs which otherwise was <20%. Both curcumin and genistein have shown good stability (>= 85%) in SIM and simulated gastric medium (SGM) up to 6 h. Coloading of curcumin and genistein had no adverse effect on solubility and stability of each molecule. Instead, coloading increased loading efficiency and the cell growth inhibition in prostate cancer cells. Collectively, these results have shown that coloaded lipid based carriers are promising vehicles for oral delivery of poorly bioaccessible molecules like curcumin and genistein.

引用

页码：1878 / 1883

页数：6

共 31 条

[1]

Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice [J].

Aditya, N. P. ;

Chimote, Geetanjali ;

Gunalan, Karthigayan ;

Banerjee, Rinti ;

Patankar, Swati ;

Madhusudhan, Basavaraj .

EXPERIMENTAL PARASITOLOGY, 2012, 131 (03) :292-299

[2]

Arthemeter-loaded lipid nanoparticles produced by modified thin-film hydration: Pharmacokinetics, toxicological and in vivo anti-malarial activity [J].

Aditya, N. P. ;

Patankar, S. ;

Madhusudhan, B. ;

Murthy, R. S. R. ;

Souto, E. B. .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 40 (05) :448-455

[3]

Prostate cancer and curcumin - Add spice to your life [J].

Aggarwal, Bharat B. .

CANCER BIOLOGY & THERAPY, 2008, 7 (09) :1438-1442

[4]

Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties [J].

Ahmed, Kashif ;

Li, Yan ;

McClements, David Julian ;

Xiao, Hang .

FOOD CHEMISTRY, 2012, 132 (02) :799-807

[5]

Batchelor J. D., 2012, J MOL BIOL

[6]

Lipid nanoparticles for the delivery of poorly water-soluble drugs [J].

Bunjes, Heike .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2010, 62 (11) :1637-1645

[7]

In vitro percutaneous absorption of genistein from topical gels through human skin [J].

Chadha, Gurkishan ;

Sathigari, Sateeshkumar ;

Parsons, Daniel L. ;

Babu, R. Jayachandra .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2011, 37 (05) :498-505

[8]

Improving Bioavailability and Stability of Genistein by Complexation with High-Amylose Corn Starch [J].

Cohen, Revital ;

Schwartz, Betty ;

Peri, Irena ;

Shimoni, Eyal .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (14) :7932-7938

[9]

Genistein [J].

Dixon, RA ;

Ferreira, D .

PHYTOCHEMISTRY, 2002, 60 (03) :205-211

[10]

Impact of gastric structuring on the lipolysis of emulsified lipids [J].

Golding, Matt ;

Wooster, Tim J. ;

Day, Li ;

Xu, Mi ;

Lundin, Leif ;

Keogh, Jennifer ;

Clifton, Peter .

SOFT MATTER, 2011, 7 (07) :3513-3523

← 1 2 3 4 →