Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors

被引：78

作者：

Lien, CC ^{[1
]}

Mu, YL ^{[1
]}

Vargas-Caballero, M ^{[1
]}

Poo, MM ^{[1
]}

机构：

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nn1649

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Local GABA (c-aminobutyric acid) circuits contribute to sensory experience-dependent refinement of neuronal connections in the developing nervous system, but whether GABAergic synapses themselves can be rapidly modified by sensory stimuli is largely unknown. Here we report that repetitive light stimuli or theta burst stimulation (TBS) of the optic nerve in the developing Xenopus retinotectal system induces long-term potentiation (LTP) of glutamatergic inputs but long-term depression (LTD) of GABAergic inputs to the same tectal neuron. The LTD is due to a reduction in presynaptic GABA release and requires activation of presynaptic NMDA (N-methyl-D-aspartate) receptors (NMDARs) and coincident high-level GABAergic activity. Thus, the presynaptic NMDAR may function as a coincidence detector for adjacent glutamatergic and GABAergic activities, leading to coordinated synaptic modification by sensory experience.

引用

页码：372 / 380

页数：9

共 51 条

[1] Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn [J].