Change in antibiotic resistance of group B Streptococcus:: Impact on intrapartum management

被引:86
作者
Morales, WJ
Dickey, SS
Bornick, P
Lim, DV
机构
[1] Florida Perinatal Associates, Tampa, FL 33613 USA
[2] Univ S Florida, Dept Biol, Tampa, FL 33620 USA
[3] St Josephs Womens Hosp, Tampa, FL USA
关键词
group B Streptococcus; antibiotic resistance; Centers for Disease Control and Prevention; protocol;
D O I
10.1016/S0002-9378(99)70553-3
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Intrapartum chemoprophylaxis has resulted in a significant reduction of group B Streptococcus neonatal infection. For penicillin-allergic patients, clindamycin or erythromycin is the recommended antibiotic. The purpose of this study was to establish any pattern of antibiotic resistance of group B streptococcal clinical isolates over the past 15 years. STUDY DESIGN: Group B streptococcal isolates obtained from the lower genital tract were tested for sensitivity to ampicillin, penicillin, clindamycin, and erythromycin. The sensitivity of 100 group B streptococcal isolates retrieved in the period 1997-1998 was compared with that of 85 group B streptococcal isolates from 1980-1993. RESULTS: From 1980-1993 group B streptococcal isolates were available for testing for antibiotic resistance along with 100 isolates from a second study period 1997-1998. Of the 100 group B streptococcal isolates from 1997-1998, 18 were resistant to erythromycin, of which 5 were also resistant to clindamycin, as compared with 1 of the 85 isolates from 1980-1993 that was resistant to erythromycin (P < .001). All the isolates were sensitive to ampicillin and penicillin. All 18 resistant strains from 1997-1998 were found to be sensitive to cephalothin. CONCLUSION: Over the past 18 years there has been increased in vitro resistance of group B streptococci to both clindamycin and erythromycin. If other studies confirm these findings, modifications to the current Centers for Disease Central and Prevention recommendations may be necessary.
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页码:310 / 312
页数:3
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