Epigenetics of Stress-Related Psychiatric Disorders and Gene x Environment Interactions

被引:241
作者
Klengel, Torsten [1 ,2 ]
Binder, Elisabeth B. [1 ,2 ]
机构
[1] Max Planck Inst Psychiat, Dept Translat Res Psychiat, D-80804 Munich, Germany
[2] Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA 30322 USA
关键词
MAJOR DEPRESSIVE DISORDER; GENOME-WIDE ASSOCIATION; EARLY-LIFE STRESS; DNA-METHYLATION; GLUCOCORTICOID-RECEPTOR; TRANSCRIPTION FACTORS; NEUROLOGICAL DISEASE; COGNITIVE-BEHAVIOR; PREFRONTAL CORTEX; CHILDHOOD ABUSE;
D O I
10.1016/j.neuron.2015.05.036
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A deeper understanding of the pathomechanisms leading to stress-related psychiatric disorders is important for the development of more efficient preventive and therapeutic strategies. Epidemiological studies indicate a combined contribution of genetic and environmental factors in the risk for disease. The environment, particularly early life severe stress or trauma, can lead to lifelong molecular changes in the form of epigenetic modifications that can set the organism off on trajectories to health or disease. Epigenetic modifications are capable of shaping and storing the molecular response of a cell to its environment as a function of genetic predisposition. This provides a potential mechanism for gene-environment interactions. Here, we review epigenetic mechanisms associated with the response to stress and trauma exposure and the development of stress-related psychiatric disorders. We also look at how they may contribute to our understanding of the combined effects of genetic and environmental factors in shaping disease risk.
引用
收藏
页码:1343 / 1357
页数:15
相关论文
共 148 条
[1]   The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes [J].
Ai Ling Teh ;
Pan, Hong ;
Chen, Li ;
Ong, Mei-Lyn ;
Dogra, Shaillay ;
Wong, Johnny ;
MacIsaac, Julia L. ;
Mah, Sarah M. ;
McEwen, Lisa M. ;
Saw, Seang-Mei ;
Godfrey, Keith M. ;
Chong, Yap-Seng ;
Kwek, Kenneth ;
Kwoh, Chee-Keong ;
Soh, Shu-E. ;
Chong, Mary F. F. ;
Barton, Sheila ;
Karnani, Neerja ;
Cheong, Clara Y. ;
Buschdorf, Jan Paul ;
Stunkel, Walter ;
Kobor, Michael S. ;
Meaney, Michael J. ;
Gluckman, Peter D. ;
Holbrook, Joanna D. .
GENOME RESEARCH, 2014, 24 (07) :1064-1074
[2]   Correcting Systematic Inflation in Genetic Association Tests That Consider Interaction Effects Application to a Genome-wide Association Study of Posttraumatic Stress Disorder [J].
Almli, Lynn M. ;
Duncan, Richard ;
Feng, Hao ;
Ghosh, Debashis ;
Binder, Elisabeth B. ;
Bradley, Bekh ;
Ressler, Kerry J. ;
Conneely, Karen N. ;
Epstein, Michael P. .
JAMA PSYCHIATRY, 2014, 71 (12) :1392-1399
[3]   Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed [J].
Alt, Simone R. ;
Turner, Jonathan D. ;
Klok, Melanie D. ;
Meijer, Onno C. ;
Lakke, Egbert A. J. F. ;
DeRijk, Roel H. ;
Muller, Claude P. .
PSYCHONEUROENDOCRINOLOGY, 2010, 35 (04) :544-556
[4]  
[Anonymous], 2014, BIOL PSYCHIAT
[5]   Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder? [J].
Bahari-Javan, Sanaz ;
Sananbenesi, Farahnaz ;
Fischer, Andre .
FRONTIERS IN NEUROSCIENCE, 2014, 8
[6]   Early Life Programming and Neurodevelopmental Disorders [J].
Bale, Tracy L. ;
Baram, Tallie Z. ;
Brown, Alan S. ;
Goldstein, Jill M. ;
Insel, Thomas R. ;
McCarthy, Margaret M. ;
Nemeroff, Charles B. ;
Reyes, Teresa M. ;
Simerly, Richard B. ;
Susser, Ezra S. ;
Nestler, Eric J. .
BIOLOGICAL PSYCHIATRY, 2010, 68 (04) :314-319
[7]   Genomic patterns and context specific interpretation of DNA methylation [J].
Baubec, Tuncay ;
Schuebeler, Dirk .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2014, 25 :85-92
[8]   MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis? [J].
Bellini, Elisa ;
Pavesi, Giulio ;
Barbiero, Isabella ;
Bergo, Anna ;
Chandola, Chetan ;
Nawaz, Mohammad S. ;
Rusconi, Laura ;
Stefanelli, Gilda ;
Strollo, Marta ;
Valente, Maria M. ;
Kilstrup-Nielsen, Charlotte ;
Landsberger, Nicoletta .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2014, 8
[9]   Beyond risk, resilience, and dysregulation: Phenotypic plasticity and human development [J].
Belsky, Jay ;
Pluess, Michael .
DEVELOPMENT AND PSYCHOPATHOLOGY, 2013, 25 (04) :1243-1261
[10]   Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition [J].
Bharadwaj, Rahul ;
Peter, Cyril J. ;
Jiang, Yan ;
Roussos, Panos ;
Vogel-Ciernia, Annie ;
Shen, Erica Y. ;
Mitchell, Amanda C. ;
Mao, Wenjie ;
Whittle, Catheryne ;
Dincer, Aslihan ;
Jakovcevski, Mira ;
Pothula, Venu ;
Rasmussen, Theodore P. ;
Giakoumaki, Stella G. ;
Bitsios, Panos ;
Sherif, Ajfar ;
Gardner, Paul D. ;
Ernst, Patricia ;
Ghose, Subroto ;
Sklar, Pamela ;
Haroutunian, Vahram ;
Tamminga, Carol ;
Myers, Richard H. ;
Futai, Kensuke ;
Wood, Marcelo A. ;
Akbarian, Schahram .
NEURON, 2014, 84 (05) :997-1008