Functions of lipoprotein receptors in neurons

被引：122

作者：

Beffert, U ^{[1
]}

Stolt, PC

Herz, J

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX USA

[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF LIPID RESEARCH | 2004年 / 45卷 / 03期

关键词：

apolipoprotein E receptor-2; very low density lipoprotein receptor; reelin;

D O I：

10.1194/jlr.R300017-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions. One ligand common to all LDLR family members is apolipoprotein E (apoE), a lipid transport protein that also plays a central role in the pathogenesis of neurodegeneration in Alzheimer's disease. This review discusses the role of apoE and its receptors in the central nervous system and, in particular, the signaling mechanisms by which two members of the LDLR gene family, apoE receptor-2 and VLDL receptor, control brain development, normal neuronal positioning, and neurotransmission in the adult brain.-Beffert, U., P. C. Stolt, and J. Herz. Functions of lipoprotein receptors in neurons.

引用

页码：403 / 409

页数：7

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