Antifertility vaccines

被引:49
作者
Delves, PJ [1 ]
Lund, T [1 ]
Roitt, IV [1 ]
机构
[1] UCL, Windeyer Inst Med Sci, Dept Immunol & Mol Pathol, London W1T 4JF, England
关键词
D O I
10.1016/S1471-4906(02)02182-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The possibility of using immunization as a method of birth control has been explored actively since the 1930s, with several different sperm, egg or hormonal antigens having been studied as suitable targets for intervention. However, it is only in the past decade that the efficacy of vaccination against fertility has become established firmly in both humans and free-roaming animal populations. We will review recent progress in the continuing development of antifertility vaccines, with an emphasis on vaccines intended ultimately for use in humans, whilst highlighting also some of the notable successes achieved with vaccines produced for use in other species.
引用
收藏
页码:213 / 219
页数:7
相关论文
共 63 条
[1]  
ACEVEDO HF, 1995, CANCER, V76, P1467, DOI 10.1002/1097-0142(19951015)76:8<1467::AID-CNCR2820760826>3.0.CO
[2]  
2-A
[3]   Prospects of riboflavin carrier protein (RCP) as an antifertility vaccine in male and female mammals [J].
Adiga, PR ;
Subramanian, S ;
Rao, J ;
Kumar, M .
HUMAN REPRODUCTION UPDATE, 1997, 3 (04) :325-334
[4]  
Beagley KW, 1998, J REPROD FERTIL, P235
[5]   Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteria [J].
Beninati, C ;
Oggioni, MR ;
Boccanera, M ;
Spinosa, MR ;
Maggi, T ;
Conti, S ;
Magliani, W ;
De Bernardis, F ;
Teti, G ;
Cassone, A ;
Pozzi, G ;
Polonelli, L .
NATURE BIOTECHNOLOGY, 2000, 18 (10) :1060-1064
[6]  
Cekan SZ, 1998, J CLIN LAB ANAL, V12, P60, DOI 10.1002/(SICI)1098-2825(1998)12:1<60::AID-JCLA10>3.0.CO
[7]  
2-M
[8]   A combinatorial phage display library for the generation of specific Fab fragments recognizing human spermatozoa and inhibiting fertilizing capacity in vitro [J].
Clayton, R ;
Cooke, ID ;
Partridge, LJ ;
Moore, HDM .
BIOLOGY OF REPRODUCTION, 1998, 59 (05) :1180-1186
[9]   Advances in immunology - Autoimmune diseases [J].
Davidson, A ;
Diamond, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (05) :340-350
[10]  
DELLACHIESA M, 2001, IMMUNOLOGY, V103, P172