Is stimulation of class-I phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism

被引:15
作者
Shepherd, PR [1 ]
Siddle, K [1 ]
Nave, BT [1 ]
机构
[1] UNIV CAMBRIDGE,DEPT CLIN BIOCHEM,CAMBRIDGE,ENGLAND
关键词
D O I
10.1042/bst0250978
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:978 / 981
页数:4
相关论文
共 31 条
[1]  
Antonetti DA, 1996, MOL CELL BIOL, V16, P2195
[2]  
Azpiazu I, 1996, J BIOL CHEM, V271, P5033
[3]   Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002 [J].
Brunn, GJ ;
Williams, J ;
Sabers, C ;
Wiederrecht, G ;
Lawrence, JC ;
Abraham, RT .
EMBO JOURNAL, 1996, 15 (19) :5256-5267
[4]  
FEVERT EU, 1997, MOL CELL BIOL, V17, P190
[5]   Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene [J].
Fruman, DA ;
Cantley, LC ;
Carpenter, CL .
GENOMICS, 1996, 37 (01) :113-121
[6]  
GIORGETTI S, 1992, EUR J BIOCHEM, V207, P599
[7]   1-PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY IS REQUIRED FOR INSULIN-STIMULATED GLUCOSE-TRANSPORT BUT NOT FOR RAS ACTIVATION IN CHO CELLS [J].
HARA, K ;
YONEZAWA, K ;
SAKAUE, H ;
ANDO, A ;
KOTANI, K ;
KITAMURA, T ;
KITAMURA, Y ;
UEDA, H ;
STEPHENS, L ;
JACKSON, TR ;
HAWKINS, PT ;
DHAND, R ;
CLARK, AE ;
HOLMAN, GD ;
WATERFIELD, MD ;
KASUGA, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7415-7419
[8]   EFFECT OF THE ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE BY A THIOPHOSPHOTYROSINE PEPTIDE ON GLUCOSE-TRANSPORT IN 3T3-L1 ADIPOCYTES [J].
HERBST, JJ ;
ANDREWS, GC ;
CONTILLO, LG ;
SINGLETON, DH ;
GENEREUX, PE ;
GIBBS, EM ;
LIENHARD, GE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) :26000-26005
[9]   PHOSPHATIDYLINOSITOL 3-KINASE - STRUCTURE AND EXPRESSION OF THE 110KD CATALYTIC SUBUNIT [J].
HILES, ID ;
OTSU, M ;
VOLINIA, S ;
FRY, MJ ;
GOUT, I ;
DHAND, R ;
PANAYOTOU, G ;
RUIZLARREA, F ;
THOMPSON, A ;
TOTTY, NF ;
HSUAN, JJ ;
COURTNEIDGE, SA ;
PARKER, PJ ;
WATERFIELD, MD .
CELL, 1992, 70 (03) :419-429
[10]   CLONING OF A NOVEL, UBIQUITOUSLY EXPRESSED HUMAN PHOSPHATIDYLINOSITOL 3-KINASE AND IDENTIFICATION OF ITS BINDING-SITE ON P85 [J].
HU, P ;
MONDINO, A ;
SKOLNIK, EY ;
SCHLESSINGER, J .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (12) :7677-7688