Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasis

被引：19

作者：

Lu, Qi ^{[1
]}

Ding, Hao ^{[1
]}

Li, Weiping ^{[1
]}

机构：

[1] Fudan Univ, Dept Surg, Huadong Hosp, Shanghai 200040, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2013年 / 9卷 / 07期

关键词：

Apoptosis; cancer metastasis; cell invasion; gastrointestinal cancer; inflammation; microbiota; Toll-like receptors; NF-KAPPA-B; DOUBLE-STRANDED-RNA; HELICOBACTER-PYLORI; ANTIVIRAL RESPONSES; BACTERIAL LIGANDS; IMMUNE-RESPONSES; INNATE IMMUNITY; CUTTING EDGE; CELL-LINES; EXPRESSION;

D O I：

10.4103/0973-1482.122509

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Toll-like receptors (TLRs) serve as specific pattern recognition molecules that bind to microbial components to activate innate immunity and instruct and modulate adaptive immunity in the face of immunological danger. Accumulating evidence supports that TLR signaling pathway responses to luminal microbes participate in the development of gastrointestinal malignancies. This review summarizes current knowledge on the roles of TLR in microbiota-associated gastrointestinal cancer metastasis, focusing on TLR recognition of microbiota ligands, initiating inflammation, and promoting tumorigenesis, as well as the therapeutic strategies to target TLR. Studying the link between TLR signaling and gastrointestinal malignancies offers the possibility to identify novel ways to both prevent and treat gastrointestinal cancer.

引用

页码：S142 / S149

页数：8

共 107 条

[1]

Decreased expression of toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide [J].