Organocatalytic asymmetric domino reactions:: A cascade consisting of a Michael addition and an aldehyde α-alkylation

被引：194

作者：

Enders, Dieter ^{[1
]}

Wang, Chuan ^{[1
]}

Bats, Jan W. ^{[2
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

[2] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60439 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 39期

关键词：

alkylation; amino acids; domino reactions; organocatalysis; quaternary stereocenters;

D O I：

10.1002/anie.200802532

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A direct approach to cyclic γ-nitroaldehydes with an all-carbon-substituted quaternary stereocenter is provided by a novel organocatalytic diastereo- and enantioselective cascade consisting of a Michael addition and an aldehyde α-alkylation (see scheme). The corresponding γ-amino acids are available in two steps. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7539 / 7542

页数：4

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