Siah-1 binds and regulates the function of Numb

被引：77

作者：

Susini, L

Passer, BJ

Amzallag-Elbaz, N

Juven-Gershon, T

Prieur, S

Privat, N

Tuynder, M

Gendron, MC

Israël, A

Amson, R

Oren, M

Telerman, A

机构：

[1] Mol Engines Labs, F-75011 Paris, France

[2] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

[3] Inst Jacques Monod, Flow Cytometry Unit, F-75251 Paris 05, France

[4] Inst Pasteur, CNRS, URA 1773, F-75724 Paris, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 26期

关键词：

D O I：

10.1073/pnas.261571998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Drosophila Seven in absentia (Sina) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G(1) arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling.

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页码：15067 / 15072

页数：6

相关论文

共 45 条

[1] INVOLVEMENT OF NOTCH-1 IN MAMMALIAN RETINAL NEUROGENESIS - ASSOCIATION OF NOTCH-1 ACTIVITY WITH BOTH IMMATURE AND TERMINALLY DIFFERENTIATED CELLS [J].

AHMAD, I ;

ZAGOURAS, P ;

ARTAVANISTSAKONAS, S .

MECHANISMS OF DEVELOPMENT, 1995, 53 (01) :73-85

[2] Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: Activation of the vertebrate homologue of the Drosophila seven in absentia gene [J].

Amson, RB ;

Nemani, M ;

Roperch, JP ;

Israeli, D ;

Bougueleret, L ;

LeGall, I ;

Medhioub, M ;

LinaresCruz, G ;

Lethrosne, F ;

Pasturaud, P ;

Piouffre, L ;

Prieur, S ;

Susini, L ;

Alvaro, V ;

Millasseau, P ;

Guidicelli, C ;

Bui, H ;

Massart, C ;

Cazes, L ;

Dufour, F ;

BruzzoniGiovanelli, H ;

Owadi, H ;

Hennion, C ;

Charpak, G ;

Dausset, J ;

Calvo, F ;

Oren, M ;

Cohen, D ;

Telerman, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :3953-3957

[3] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[4] NOTCH SIGNALING [J].

ARTAVANISTSAKONAS, S ;

MATSUNO, K ;

FORTINI, ME .

SCIENCE, 1995, 268 (5208) :225-232

[5] Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling [J].

Berezovska, O ;

Jack, C ;

McLean, P ;

Aster, JC ;

Hicks, C ;

Xia, WM ;

Wolfe, MS ;

Kimberly, WT ;

Weinmaster, G ;

Selkoe, DJ ;

Hyman, BT .

JOURNAL OF NEUROCHEMISTRY, 2000, 75 (02) :583-593

[6] SIAH-1 inhibits cell growth by altering the mitotic process [J].

Bruzzoni-Giovanelli, H ;

Faille, A ;

Linares-Cruz, G ;

Nemani, M ;

Le Deist, F ;

Germani, A ;

Chassoux, D ;

Millot, G ;

Roperch, JP ;

Amson, R ;

Telerman, A ;

Calvo, F .

ONCOGENE, 1999, 18 (50) :7101-7109

[7] 7 IN ABSENTIA, A GENE REQUIRED FOR SPECIFICATION OF R7 CELL FATE IN THE DROSOPHILA EYE [J].

CARTHEW, RW ;

RUBIN, GM .

CELL, 1990, 63 (03) :561-577

[8] IDENTIFICATION OF GENES THAT INTERACT WITH THE SINA GENE IN DROSOPHILA EYE DEVELOPMENT [J].

CARTHEW, RW ;

NEUFELD, TP ;

RUBIN, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11689-11693

[9]

DELLA NG, 1993, DEVELOPMENT, V117, P1333

[10] INTERACTION MATING REVEALS BINARY AND TERNARY CONNECTIONS BETWEEN DROSOPHILA CELL-CYCLE REGULATORS [J].

FINLEY, RL ;

BRENT, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12980-12984

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