Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome

被引:193
作者
Taniguchi, T [1 ]
Koido, Y [1 ]
Aiboshi, J [1 ]
Yamashita, T [1 ]
Suzaki, S [1 ]
Kurokawa, A [1 ]
机构
[1] Tama Nagayama Hosp, Nippon Med Sch, Dept Emergency & Crit Care Med, Tama, Japan
关键词
interleukin-10; interleukin-6; systemic inflammatory response syndrome; sepsis; multiple organ Failure; inflammation; cytokine; critical illness;
D O I
10.1097/00003246-199907000-00005
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: To examine whether changes in interleukin (IL)-6 and IL-10 concentrations in patients with systemic inflammatory response syndrome (SIRS) can predict a poor outcome. Design:Prospective study. Selling: Emergency and intensive care unit of a medical school hospital. Patients: Twenty-five patients who fulfilled the criteria for SIRS. Interventions: Blood samples were collected for cytokine determinations. Measurements and Main Results: IL-6 and IL-10 concentrations were measured by enzyme-linked immunosorbent assay in plasma samples. Blood samples were obtained at 0, 1, 2, and 4 days from patients who fulfilled the criteria for SIRS. Of 25 patients, 19 survived and the other six patients died of multiple organ failure. Although IL-6 and IL-10 concentrations in survivors decreased gradually from 186.1 +/- 34.4 to 93.6 +/- 18.9 (SEM) pg/mL (p < .05) and from 77.4 +/- 21.2 to 32.0 +/- 11.8 pg/mL (p < .05), IL-6 concentrations in nonsurvivors did not Although the ratio of IL-6 to IL-IO in survivors was almost stable, the ratio in nonsurvivors increased from 5.5 +/- 3.1 to 18.7 +/- 2.8 (p < .05), Multivariate analysis showed that when heart rate, mean arterial pressure, IL-6, IL-10, and the ratio of IL-g to IL-10 were taken into account, there only remained a relationship between the ratio of IL-6 to IL-10 and outcome, Conclusions: In nonsurvivors, IL-6 concentrations did not decrease, IL-10 concentration decreased, and the ratio of IL-6 to IL-10 increased. An increase in the ratio of IL-6 to IL-10 indicated a correlation with a poor outcome.
引用
收藏
页码:1262 / 1264
页数:3
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