The methylation status of FBXW7 β-form correlates with histological subtype in human thymoma

被引：13

作者：

Gu, Zhaodi ^{[1
]}

Mitsui, Hidetoshi ^{[1
]}

Inomata, Kenichi ^{[1
]}

Honda, Masako ^{[2
]}

Endo, Chiaki ^{[2
]}

Sakurada, Akira ^{[2
]}

Sato, Masami ^{[3
]}

Okada, Yoshinori ^{[2
]}

Kondo, Takashi ^{[2
]}

Horii, Akira ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Inst Dev Aging & Canc, Dept Thorac Surg, Aoba Ku, Sendai, Miyagi 9808575, Japan

[3] Miyagi Canc Ctr Hosp, Div Thorac Surg, Natori, Miyagi 9811293, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 377卷 / 02期

关键词：

Methylation; FBXW7; beta-form; Thymoma;

D O I：

10.1016/j.bbrc.2008.10.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma: although no mutations were evident, a significantly high frequency of methylation in the FBXW7 beta-form promoter was observed in types B1 or higher (P = 0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 beta-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：685 / 688

页数：4

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