Serum IGF-1 levels correlate negatively to liver damage in diabetic rats

被引：35

作者：

Aksu, Ilkay ^{[1
]}

Baykara, Basak ^{[2
]}

Kiray, Muge ^{[1
]}

Gurpinar, Tugba ^{[3
]}

Sisman, Ali Riza ^{[1
]}

Ekerbicer, Nuran ^{[3
]}

Tas, Aysegul ^{[1
]}

Gokdemir-Yazar, Ozden ^{[1
]}

Uysal, Nazan ^{[1
]}

机构：

[1] Dokuz Eylul Univ, Fac Med, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, High Sch Phys Therapy & Rehabil, TR-35340 Izmir, Turkey

[3] Celal Bayar Univ, Fac Med, Manisa, Turkey

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2013年 / 88卷 / 3-4期

关键词：

diabetes mellitus; IGF-1; liver damage; oxidative stress; streptozotocin; GROWTH-FACTOR-I; SUPEROXIDE-DISMUTASE; GLUTATHIONE LEVELS; OXIDATIVE STRESS; AMINOTRANSFERASE; STREPTOZOTOCIN; DISEASE; EXPRESSION; GENE;

D O I：

10.3109/10520295.2012.758311

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Diabetes and insulin resistance frequently cause liver damage. Diabetes also causes reduction in liver and blood IGF-1 levels. We investigated the relation between liver damage and IGF-1 levels in diabetic rats. Fourteen Wistar albino rats were divided into control and diabetic groups. Diabetes was induced by streptozotocin. Rats were sacrificed for biochemical and histologic examinations 2 weeks after streptozotocin injection. Serum and liver IGF-1 levels were decreased, liver malondialdehyde (MDA) levels were increased, glutathione peroxidase (GPx) enzymes activities were decreased and serum alanine aminotransferase (ALT) levels were increased in diabetic group. Microscopic examination of liver revealed that normal tissue organization was disrupted in streptozotocin-induced diabetic rats. There was a strongly positive correlation between blood glucose levels and liver injury, and blood and liver IGF-1 levels. There was a strongly negative correlation between blood IGF-1 levels and hepatic injury. Our results suggest that reduction of blood IGF-1 levels correlates with hepatic injury and circulating IGF-1 levels may have predictive value for determining hepatic damage that results from diabetes. In addition, circulating IGF-1 levels are correlated with glutathione levels and the oxidative stress status of diabetic rat liver.

引用

页码：194 / 201

页数：8

共 35 条

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