Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons

被引：79

作者：

Gilca, R

De Serres, G

Tremblay, M

Vachon, ML

Leblanc, E

Bergeron, MG

Déry, P

Boivin, G

机构：

[1] Univ Laval, Quebec City, PQ, Canada

[2] Quebec Natl Inst Publ Hlth, Quebec City, PQ, Canada

[3] Res Ctr Infect Dis, Quebec City, PQ, Canada

[4] Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 01期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1086/498526

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children <= 3 years old over 2 winters. Clinical data were compared between 106 children infected with group A hRSV (96 GA2 genotypes) and 94 children infected with hRSV group B (62 GB3 genotypes). A severity index was defined by assigning 1 point each for the use of > 30% supplemental oxygen, admission to an intensive-care unit, and duration of hospital stay of 15 days. Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains.

引用

页码：54 / 58

页数：5

共 15 条

[1] Boivin G, 2003, EMERG INFECT DIS, V9, P634
[2] OCCURRENCE OF GROUP-A AND GROUP-B OF RESPIRATORY SYNCYTIAL VIRUS OVER 15 YEARS - ASSOCIATED EPIDEMIOLOGIC AND CLINICAL CHARACTERISTICS IN HOSPITALIZED AND AMBULATORY CHILDREN
HALL, CB
WALSH, EE
SCHNABEL, KC
LONG, CE
MCCONNOCHIE, KM
HILDRETH, SW
ANDERSON, LJ
[J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (06) : 1283 - 1290
[3] Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children
Iwane, MK
Edwards, KM
Szilagyi, PG
Walker, FJ
Griffin, MR
Weinberg, GA
Coulen, C
Poehling, KA
Shone, LP
Balter, S
Hall, CB
Erdman, DD
Wooten, K
Schwartz, B
[J]. PEDIATRICS, 2004, 113 (06) : 1758 - 1764
[4] THE G-GLYCOPROTEIN OF HUMAN RESPIRATORY SYNCYTIAL VIRUSES OF SUBGROUP-A AND SUBGROUP-B - EXTENSIVE SEQUENCE DIVERGENCE BETWEEN ANTIGENICALLY RELATED PROTEINS
JOHNSON, PR
SPRIGGS, MK
OLMSTED, RA
COLLINS, PL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) : 5625 - 5629
[5] Correlation between respiratory syncytial virus genotype and severity of illness
Martinello, RA
Chen, MD
Weibel, C
Kahn, JS
[J]. JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (06) : 839 - 842
[6] VARIATION IN SEVERITY OF RESPIRATORY SYNCYTIAL VIRUS-INFECTIONS WITH SUBTYPE
MCCONNOCHIE, KM
HALL, CB
WALSH, EE
ROGHMANN, KJ
[J]. JOURNAL OF PEDIATRICS, 1990, 117 (01) : 52 - 62
[7] MCINTOSH EDG, 1993, PEDIATR INFECT DIS J, V12, P815, DOI 10.1097/00006454-199310000-00004
[8] Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community
Peret, TCT
Hall, CB
Schnabel, KC
Golub, JA
Anderson, LJ
[J]. JOURNAL OF GENERAL VIROLOGY, 1998, 79 : 2221 - 2229
[9] Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America
Peret, TCT
Hall, CB
Hammond, GW
Piedra, PA
Storch, GA
Sullender, WM
Tsou, C
Anderson, LJ
[J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (06) : 1891 - 1896
[10] Driscoll Children's Hospital respiratory syncytial virus database - Risk factors, treatment and hospital course in 3308 infants and young children, 1997 to 2002
Purcell, K
Fergie, J
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2004, 23 (05) : 418 - 423

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