Piperine, the potential functional food for mood and cognitive disorders

被引：128

作者：

Wattanathorn, Jintanaporn ^{[1
]}

Chonpathompikunlert, Pennapa ^{[1
,2
]}

Muchimapura, Supaporn ^{[1
]}

Priprem, Aroonsi ^{[3
]}

Tankamnerdthai, Orathai ^{[1
]}

机构：

[1] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Med, Grad Sch, Neurosci Program, Khon Kaen 40002, Thailand

[3] Khon Kaen Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, Khon Kaen 40002, Thailand

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 09期

关键词：

piperine; anti-depression like activity; cognitive enhancing effect; spatial memory;

D O I：

10.1016/j.fct.2008.06.014

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effect of piperine, the main alkaloid front piper nigrum. oil the central nervous system is not clearly known until now. In the present Study, male Wistar rats were administered piperine at various doses ranging from 5, 10 and 20 mg/kg BW once daily for 4 weeks and the animals were determined the neuropharmacological activity after single, 1, 2, 3 and 4 weeks of treatment. The results showed that piperine at all dosage range used in this study possessed anti-depression like activity and cognitive enhancing effect at all treatment duration. Therefore, piperine may be served as the potential functional food to improve brain function. However, further investigations about precise underlying mechanism are still required. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3106 / 3110

页数：5

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