Coordinated protein sorting, targeting and distribution in polarized cells

被引:394
作者
Mellman, Ira [1 ]
Nelson, W. James [2 ,3 ]
机构
[1] Genentech Inc, San Francisco, CA 94080 USA
[2] Stanford Univ, Dept Biol, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
[3] Stanford Univ, Bio X Program, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrm2525
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.
引用
收藏
页码:833 / 845
页数:13
相关论文
共 133 条
[1]   Polarization of the C-elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts [J].
Anderson, Dorian C. ;
Gill, Jason S. ;
Cinalli, Ryan M. ;
Nance, Jeremy .
SCIENCE, 2008, 320 (5884) :1771-1774
[2]   Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells [J].
Ang, AL ;
Taguchi, T ;
Francis, S ;
Fölsch, H ;
Murrells, LJ ;
Pypaert, M ;
Warren, G ;
Mellman, I .
JOURNAL OF CELL BIOLOGY, 2004, 167 (03) :531-543
[3]   Key regulators in neuronal polarity [J].
Arimura, N ;
Kaibuchi, K .
NEURON, 2005, 48 (06) :881-884
[4]   Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6-aPKC [J].
Atwood, Scott X. ;
Chabu, Chiswili ;
Penkert, Rhiannon R. ;
Doe, Chris Q. ;
Prehoda, Kenneth E. .
JOURNAL OF CELL SCIENCE, 2007, 120 (18) :3200-3206
[5]   Mammalian scribble forms a tight complex with the βPIX exchange factor [J].
Audebert, S ;
Navarro, C ;
Nourry, C ;
Chasserot-Golaz, S ;
Lécine, P ;
Bellaiche, Y ;
Dupont, JL ;
Premont, RT ;
Sempéré, C ;
Strub, JM ;
Van Dorsselaer, A ;
Vitale, N ;
Borg, JP .
CURRENT BIOLOGY, 2004, 14 (11) :987-995
[6]   Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD [J].
Baas, AF ;
Kuipers, J ;
van der Wel, NN ;
Batlle, E ;
Koerten, HK ;
Peters, PJ ;
Clevers, HC .
CELL, 2004, 116 (03) :457-466
[7]   POLARITY ORIENTATION OF MICROTUBULES IN HIPPOCAMPAL-NEURONS - UNIFORMITY IN THE AXON AND NONUNIFORMITY IN THE DENDRITE [J].
BAAS, PW ;
DEITCH, JS ;
BLACK, MM ;
BANKER, GA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8335-8339
[8]   THE SUBCELLULAR ORGANIZATION OF MADIN-DARBY CANINE KIDNEY-CELLS DURING THE FORMATION OF A POLARIZED EPITHELIUM [J].
BACALLAO, R ;
ANTONY, C ;
DOTTI, C ;
KARSENTI, E ;
STELZER, EHK ;
SIMONS, K .
JOURNAL OF CELL BIOLOGY, 1989, 109 (06) :2817-2832
[9]   Organizing the diseases fluid membrane bilayer: diseases linked to spectrin and ankyrin [J].
Bennett, Vann ;
Healy, Jane .
TRENDS IN MOLECULAR MEDICINE, 2008, 14 (01) :28-36
[10]   Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells [J].
Benton, R ;
St Johnston, D .
CELL, 2003, 115 (06) :691-704