共 133 条
Coordinated protein sorting, targeting and distribution in polarized cells
被引:394
作者:

Mellman, Ira
论文数: 0 引用数: 0
h-index: 0
机构:
Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USA

Nelson, W. James
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biol, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
Stanford Univ, Bio X Program, Stanford, CA 94305 USA Genentech Inc, San Francisco, CA 94080 USA
机构:
[1] Genentech Inc, San Francisco, CA 94080 USA
[2] Stanford Univ, Dept Biol, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
[3] Stanford Univ, Bio X Program, Stanford, CA 94305 USA
基金:
美国国家卫生研究院;
关键词:
D O I:
10.1038/nrm2525
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.
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页码:833 / 845
页数:13
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