Studies on immunoregulatory and anti-tumor activities of a polysaccharide from Salvia miltiorrhiza Bunge

被引：143

作者：

Liu, Lei ^{[1
]}

Jia, Jun ^{[2
]}

Zeng, Guang ^{[3
]}

Zhao, Yan ^{[1
]}

Qi, Xingshun ^{[1
]}

He, Chuangye ^{[1
]}

Guo, Wengang ^{[1
]}

Fan, Daiming ^{[4
,5
]}

Han, Guohong ^{[1
]}

Li, Zhanting ^{[6
]}

机构：

[1] Fourth Mil Med Univ, Dept Digest Intervent Radiol, Xijing Hosp Digest Dis, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Hlth Serv, Sch Mil Prevent Med, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Dept Orthodont, Sch Stomatol, Xian 710032, Peoples R China

[4] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710038, Peoples R China

[5] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710038, Peoples R China

[6] Fourth Mil Med Univ, Div Nephrol, Tangdu Hosp, Xian 710038, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 92卷 / 01期

关键词：

Salvia miltiorrhiza; Polysaccharide; Anticancer; Hepatocellular carcinoma H22; Immunoregulatory; TANSHINONES; CARCINOMA; GROWTH;

D O I：

10.1016/j.carbpol.2012.09.061

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

In this study, we purified and characterized a polysaccharide (SMP-W1) from Salvia miltiorrhiza and investigated its anticancer and immunoregulatory potential in vitro and in vivo. The monosaccharide composition, protein content, uronic acid content, total carbohydrate content, viscosity and molecular weight of SMP-W1 were analyzed. In vitro, SMP-W1 had an antiproliferative effect on hepatocellular carcinoma H22 cells, especially at the high concentration of 400 mu g/ml. Simultaneously the polysaccharide SMP-W1 significantly inhibited tumor growth and increased serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in rats, as well as the secretion of TNF-alpha. In addition, the body weight, spleen index and thymus index in tumor-bearing mice were significantly improved by SMP-W1 treatment. Taken together, these results indicated that SMP-W1 possessed strong in vivo and in vitro anti-tumor activity and improves the immune response in tumor-bearing mice. Therefore, it could be developed as an anti-tumor agent with immunomodulatory activity. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：479 / 483

页数：5

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