The microbiome explored: recent insights and future challenges

被引：128

作者：

Blaser, Martin ^{[1
,2
]}

Bork, Peer ^{[3
]}

Fraser, Claire ^{[4
,5
]}

Knight, Rob ^{[6
,7
]}

Wang, Jun ^{[8
]}

机构：

[1] NYU, Dept Med, Langone Med Ctr, New York, NY 10016 USA

[2] NYU, Dept Microbiol, Langone Med Ctr, New York, NY 10016 USA

[3] EMBL, D-69115 Heidelberg, Germany

[4] Univ Maryland, Sch Med, Inst Genome Sci, Dept Med, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[6] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[7] Howard Hughes Med Inst, Boulder, CO 80309 USA

[8] BGI, Shenzhen 518083, Peoples R China

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 03期

关键词：

D O I：

10.1038/nrmicro2973

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One of the most exciting scientific advances in recent years has been the realization that commensal microorganisms are not simple 'passengers' in our bodies, but instead have key roles in our physiology, including our immune responses and metabolism, as well as in disease. These insights have been obtained, in part, through the work of large-scale, consortium-driven metagenomic projects. Here, five experts in the field of microbiome research discuss the most surprising and exciting new findings, and outline the future steps that will be necessary to elucidate the numerous roles of the microbiota in human health and disease and to develop viable therapeutic strategies.

引用

页码：213 / 217

页数：5

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