Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor

被引：40

作者：

Miyata, S ^{[1
]}

Wang, LY

Yoshida, C

Kitanaka, S

机构：

[1] Nihon Univ, Coll Humanities & Sci, Dept Chem, Setagaya Ku, Tokyo 1568550, Japan

[2] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[3] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 06期

关键词：

Euphorbia kansui; diterpene; inhibition of cell proliferation; inhibition of topoisomerase II; Xenopus embryo cell;

D O I：

10.1016/j.bmc.2005.10.059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We examined the effects of 12 terpene compounds derived from the roots of Euphorbia kansui on the proliferative activity of Xenopus embryo cells. Eight of these compounds showed significant inhibition of cellular proliferation even at low concentrations, while four of them needed to be present at higher concentrations to inhibit cellular proliferation. In order to define the mechanism of inhibition of cellular proliferation by these compounds, the effects of diterpene compounds on the activity of topoisomerase II were measured. Most of the diterpene compounds that inhibited cellular proliferation also inhibited topoisomerase II activity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2048 / 2051

页数：4

共 15 条

[1]

Anderson H, 1996, CELL GROWTH DIFFER, V7, P83

[2]

ANDOH T, 1998, BIOCHIM BIOPHYS ACTA, V1400, P1155

[3]

DNA TOPOISOMERASES [J].