Bone augmentation with bioactive glass in three cases of dental implant placement

This study reports the clinical use of a bioactive bone graft material, PerioGlas (R), in the treatment of dental extraction sites before dental implant placement, to effect bone regeneration and to give early fixation to the implant. PerioGlas (R), granules, ranging from 90 to 710 pm, are implanted after tooth extraction in three patients; after 6 months bone biopsies were performed in the site of the glass implantation and observed under Electron Scanning Microscopy. All the granules showed a biodegradation involving precipitation of calcium phosphate that worked as a scaffold for osteoblasts colonization. All cases examined showed the bioactivity of PerioGlas (R) granules resulting in new bone formation and biodegradation of the glass. After a two-year clinical follow-up all the implants were successfully loaded and appeared stable.