Quantification of the co-mutagenic β-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods

被引:112
作者
Totsuka, Y
Ushiyama, H
Ishihara, J
Sinha, R
Goto, S
Sugimura, T
Wakabayashi, K
机构
[1] Natl Canc Ctr, Res Inst, Canc Prevent Div, Chuo Ku, Tokyo 1040045, Japan
[2] Tokyo Metropolitan Res Lab Publ Hlth, Div Food Hyg, Shinjuku Ku, Tokyo 1690073, Japan
[3] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[4] Natl Inst Publ Hlth, Dept Community Environm Sci, Minato Ku, Tokyo 1088638, Japan
关键词
norharman; harman; cigarette smoke; cooked food;
D O I
10.1016/S0304-3835(99)00143-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Co-mutagenic beta-carbolines, such as norharman and harman, were quantified in mainstream and sidestream smoke condensates of six Japanese brands of cigarettes; and also in 13 kinds of cooked foods, using a combination of blue cotton treatment and HPLC. Norharman and harman were detected in all the cigarette smoke condensate samples. Their levels in the mainstream smoke case were 900-4240 ng per cigarette for norharman, and 360-2240 ng for harman, and in sidestream smoke, 4130-8990 ng for norharman and 2100-3000 ng for harman. These beta-carbolines were also found to be present in all the cooked food samples, at levels of 2.39-795 ng for norharman and 0.62-377 ng for harman per gram of cooked food. The observed concentrations are much higher than those found for mutagenic and carcinogenic heterocyclic amines (HCAs), suggesting that humans are exposed to norharman and harman in daily life to a larger extent than to HCAs. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:139 / 143
页数:5
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