Varicella-zoster virus DNA in CSF and arteries in delayed contralateral hemiplegia: Evidence for viral invasion of cerebral arteries

被引：54

作者：

Melanson, M ^{[1
]}

Chalk, C ^{[1
]}

Georgevich, L ^{[1
]}

Fett, K ^{[1
]}

Lapierre, Y ^{[1
]}

Duong, H ^{[1
]}

Richardson, J ^{[1
]}

Marineau, C ^{[1
]}

Rouleau, GA ^{[1
]}

机构：

[1] MCGILL UNIV,MONTREAL,PQ,CANADA

来源：

NEUROLOGY | 1996年 / 47卷 / 02期

关键词：

D O I：

10.1212/WNL.47.2.569

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 78-year-old woman presented with a right basal ganglia infarct 6 weeks after a left herpes tester ophthalmicus. MR angiography showed focal segmental stenosis of the proximal segments of the anterior, middle, and posterior cerebral arteries. Varicella DNA was detected in the CSF by polymerase chain reaction (PCR). Treated with dexamethasone and acyclovir without improvement, she died 1 month later. There was focal endarteritis in the left anterior, middle, and posterior cerebral arteries at autopsy. Varicella DNA was detected by PCR of extracts from these vessels but not from the arteries on the right side. This study provides further evidence that the vasculopathy after herpes tester ophthalmicus results from direct viral invasion of the vessel wall.

引用

页码：569 / 570

页数：2

共 10 条

[1] CEREBRAL VASCULOPATHY ASSOCIATED WITH PRIMARY VARICELLA INFECTION [J].