Cell biology - Snail mail to the nucleus

被引：14

作者：

Mattaj, IW ^{[1
]}

Conti, E ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

NATURE | 1999年 / 399卷 / 6733期

关键词：

D O I：

10.1038/20322

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Large molecules are constantly shuffled between the nucleus and cytoplasm via channels called nuclear-pore complexes. Transport is mediated by receptor proteins called importins and exportins, which bind the cargo and shuttle it through the pore. The crystal structures of two importins — one with its cargo and one with the GTP-bound form of the small GTPase Ran — are now reported. There are telling similarities and differences between these two structures.

引用

页码：208 / 210

页数：3

共 13 条

[1] HEAT REPEATS IN THE HUNTINGTONS-DISEASE PROTEIN
ANDRADE, MA
BORK, P
[J]. NATURE GENETICS, 1995, 11 (02) : 115 - 116
[2] Structure of the nuclear transport complex karyopherin-β2-Ran•GppNHp
Chook, YM
Blobel, G
[J]. NATURE, 1999, 399 (6733) : 230 - 237
[3] Structure of importin-β bound to tbe IBB domain of importin-α
Cingolani, G
Petosa, C
Weis, K
Müller, CW
[J]. NATURE, 1999, 399 (6733) : 221 - 229
[4] Fridell RA, 1997, J CELL SCI, V110, P1325
[5] A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus
Gorlich, D
Henklein, P
Laskey, RA
Hartmann, E
[J]. EMBO JOURNAL, 1996, 15 (08) : 1810 - 1817
[6] The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
Groves, MR
Hanlon, N
Turowski, P
Hemmings, BA
Barford, D
[J]. CELL, 1999, 96 (01) : 99 - 110
[7] Nucleocytoplasmic transport: The soluble phase
Mattaj, IW
Englmeier, L
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 : 265 - 306
[8] The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence
Moroianu, J
Blobel, G
Radu, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) : 6572 - 6576
[9] MAMMALIAN KARYOPHERIN ALPHA(1)BETA AND ALPHA(2)BETA HETERODIMERS - ALPHA(1) OR ALPHA(2) SUBUNIT BINDS NUCLEAR-LOCALIZATION SIGNAL AND BETA-SUBUNIT INTERACTS WITH PEPTIDE REPEAT-CONTAINING NUCLEOPORINS
MOROIANU, J
HIJIKATA, M
BLOBEL, G
RADU, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) : 6532 - 6536
[10] A novel receptor-mediated nuclear protein import pathway
Pollard, VW
Michael, WM
Nakielny, S
Siomi, MC
Wang, F
Dreyfuss, G
[J]. CELL, 1996, 86 (06) : 985 - 994

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