Brain serotonin transporter binding of [123I]ADAM:: Within-subject variation between summer and winter data

被引：16

作者：

Koskela, Anu ^{[1
]}

Kauppinen, Tomi ^{[2
]}

Keski-Rahkonen, Anna ^{[3
]}

Sihvola, Elina ^{[3
]}

Kaprio, Jaakko ^{[3
,4
]}

Rissanen, Aila ^{[5
]}

Ahonen, Aapo ^{[1
]}

机构：

[1] Univ Helsinki, Cent Hosp, HUSLAB, Dept Clin Physiol & Nucl Med, FI-00029 Helsinki, Finland

[2] Univ Helsinki, Cent Hosp, Helsinki Med Imaging Ctr, FI-00029 Helsinki, Finland

[3] Univ Helsinki, Dept Publ Hlth, Finnish Twin Cohort Study, FI-00029 Helsinki, Finland

[4] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, Helsinki, Finland

[5] Univ Helsinki, Dept Psychiat, Obes Res Unit, FI-00029 Helsinki, Finland

来源：

CHRONOBIOLOGY INTERNATIONAL | 2008年 / 25卷 / 05期

关键词：

SPECT; 5-HT; SERT; I-123] ADAM; seasonal variation;

D O I：

10.1080/07420520802380000

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The neurotransmitter serotonin (5-HT) controls several physiological functions, and a disturbance of the 5-HT system is implicated in many psychiatric conditions. Seasonal variation has been suggested in the 5-HT system. We investigated within-subject seasonal variation in brain serotonin transporter (SERT) binding with the SERT-ligand [I-123]ADAM and single photon emission computed tomography (SPECT) in 12 healthy individuals. No systematic variation was found in the midbrain or thalamus areas between scans done in summer and winter. Our results suggest that factors other than season are more important in causing within-subject variation of brain SERT binding between summer and winter.

引用

页码：657 / 665

页数：9

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