Novel extended-spectrum TEM-type beta-lactamase from an Escherichia coli isolate resistant to ceftazidime and susceptible to cephalothin

被引：12

作者：

ChanalClaris, C

Sirot, D

Bret, L

Chatron, P

Labia, R

Sirot, J

机构：

[1] LAB ANAL MED MONIER CHATRON,F-63000 CLERMONT FERRAN,FRANCE

[2] MNHN,UMR 175,CNRS,F-29000 QUIMPER,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 03期

关键词：

D O I：

10.1128/AAC.41.3.715

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel extended-spectrum TEM-type beta-lactamase was detected in an Escherichia coli isolate which was resistant to ceftazidime and susceptible to cephalothin. The corresponding bla gene was sequenced. The deduced amino acid sequence showed the following three amino acid replacements with respect to the TEM-2 sequence: Glu-->Lys-104, Arg-->Ser-164, and Glu-->Lys-240. Since it confers a ceftazidimase-type resistance phenotype, we propose for this novel enzyme the designation CAZ-9, corresponding to TEM-46 in the sequential numbering scheme of TEM beta-lactamases.

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页码：715 / 716

页数：2

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