Carborundum, a bulk similar to dietary fibers but chemically inert, does not decrease colon carcinogenesis

被引:8
作者
Corpet, DE
Tache, S
Peiffer, G
机构
关键词
fibers; bulk; carcinogenesis; carborundum; aberrant crypt foci;
D O I
10.1016/S0304-3835(97)04619-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Dietary fibers might lower the risk of colorectal cancer, maybe because of their bulking effect. We tested the protection afforded by an inert bulk against carcinogenesis. Thirty rats received an azoxymethane injection and were allocated to a control diet, or to a diet supplemented with 10% carborundum. After 100 days the colons were scored for aberrant crypt foci. Compared to controls, the fecal weight was doubled in carborundum-fed rats (P < 0.001), but the aberrant crypt foci multiplicity was not changed (P = 0.92). The results do not support the hypothesis that intestinal dilution by an inert bulk can protect against colon cancer. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:35 / 38
页数:4
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