Element- and isotope-specific detection for high-performance liquid chromatography using chemical reaction interface mass spectrometry

被引：22

作者：

McLean, M

Vestal, ML

Teffera, Y

Abramson, FP

机构：

[1] GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL RE6640,WASHINGTON,DC 20037

[2] VESTEC MASS SPECTROMETRY PROD,PERSEPT BIOSYS,HOUSTON,TX 77054

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 732卷 / 02期

关键词：

detection; LC; mass spectrometry; chemical reaction interface mass spectrometry; element-specific detection; isotope-specific detection;

D O I：

10.1016/0021-9673(95)01279-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed a combination of high-performance liquid chromatography (HPLC) and the chemical reaction interface mass spectrometry (CRIMS) method by using a Vestee Universal Interface (UI). This interface provides the extremely high degree of solvent removal that the CRIMS process requires. In doing so, we have produced an HPLC detector with the ability to carry out element- and isotope-selective analyses with detection that is inherently: linear, structure-independent, sensitive, selective, comprehensive and flexible. The characteristics of the instrumentation and its performance are described.

引用

页码：189 / 199

页数：11

共 23 条

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