Noninvasive temperature measurement in vivo using a temperature-sensitive lanthanide complex and H-1 magnetic resonance spectroscopy

被引:50
作者
Frenzel, T [1 ]
Roth, K [1 ]
Kossler, S [1 ]
Raduchel, B [1 ]
Bauer, H [1 ]
Platzek, J [1 ]
Weinmann, HJ [1 ]
机构
[1] FREE UNIV BERLIN,INST ORGAN CHEM,W-1000 BERLIN,GERMANY
关键词
lanthanide complexes; temperature measurement; in vivo H-1 magnetic resonance spectroscopy;
D O I
10.1002/mrm.1910350314
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A new lanthanide complex, praseodymium-2-methoxyethyl-DO3A, was tested as a temperature indicator for H-1 magnetic resonance spectroscopy under in vivo conditions, using a 2-T imaging system. The chemical shift of the methoxy group of the compound is strongly temperature dependent. In vitro, a shift change of -0.131 ppm/degrees C was found. The signal was shifted by about -24 ppm relative to the water signal, allowing easy water suppression and signal identification in vivo. The body temperatures of eight anesthetized rats were measured in the liver after intravenous administration of 1 mmol/kg of the praseodymium complex under different heating conditions of the animal. The temperatures calculated from the spectra were in good agreement (deviation < +/- 1 degrees C) with values obtained simultaneously with a thermocouple placed in the rectum of the animals.
引用
收藏
页码:364 / 369
页数:6
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