Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome

被引:12
作者
Alper, Ahmet Taha [1 ]
Sevimli, Serdar [2 ]
Hasdemir, Hakan [1 ]
Nurkalem, Zekeriya [1 ]
Guevenc, Tolga Sinan [1 ]
Akyol, Ahmet [1 ]
Cakmak, Nazmiye [1 ]
Durmus, Guenduez [1 ]
Guerkan, Kadir [1 ]
机构
[1] Dr Siyami Ersek Thorac & Vasc Surg Ctr, Istanbul, Turkey
[2] Ataturk Univ, Dept Cardiol, Med Sch Hosp, Erzurum, Turkey
关键词
Mean platelet volume; Platelet count; Acute coronary syndrome; High altitude; MYOCARDIAL-INFARCTION; UNSTABLE ANGINA; ARTERY DISEASE; ERYTHROPOIETIN; SIZE; REACTIVITY; THROMBOSIS; EXPOSURE; TIBETANS; HYPOXIA;
D O I
10.1007/s11239-007-0159-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A relationship exists between exposure to high altitude and increased coagulability. Mean platelet volume is a parameter of platelet functions and may be a marker for increased platelet aggregability. The aim of this study was to compare the mean platelet volumes and platelet counts in patients who experienced an acute coronary event at moderately high altitude and at sea altitude. Four hundred and one patients who experienced an acute coronary event were enrolled, of them 211 were born and had been living at the sea level, while 190 were born and had been living at high altitude (at least 2,000 m above the sea level). Patients were compared regarding the mean platelet volumes and platelet counts. The mean platelet volumes were significantly higher in patients living in high altitude (P = 0,001). No statistically significant differences were found among the groups regarding the platelet counts. As a result, this increased MPV values in highlanders who experienced an acute coronary event may reflect increased platelet aggregability.
引用
收藏
页码:130 / 134
页数:5
相关论文
共 36 条
[1]  
ALHUTHI MA, 2006, MEDGENMED, V7, P28
[2]   Symptomatic portal system thrombosis in soldiers due to extended stay at extreme altitude [J].
Anand, AC ;
Saha, A ;
Seth, AK ;
Chopra, GS ;
Nair, V ;
Sharma, V .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 20 (05) :777-783
[3]   Platelet size: Measurement, physiology and vascular disease [J].
Bath, PMW ;
Butterworth, RJ .
BLOOD COAGULATION & FIBRINOLYSIS, 1996, 7 (02) :157-161
[4]  
Beall CM, 1998, AM J PHYS ANTHROPOL, V106, P385, DOI 10.1002/(SICI)1096-8644(199807)106:3<385::AID-AJPA10>3.0.CO
[5]  
2-X
[6]   Mean platelet volume in patients with isolated coronary artery ectasia [J].
Bitigen, Atila ;
Tanalp, Ali Cevat ;
Elonu, Orhan Hakan ;
Karavelioglu, Yusuf ;
Ozdemir, Nihal .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2007, 24 (02) :99-103
[7]   ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-2002: Summary article - A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina) [J].
Braunwald, E ;
Antman, EM ;
Beasley, JW ;
Califf, RM ;
Cheitlin, MD ;
Hochman, JS ;
Jones, RH ;
Kereiakes, D ;
Kupersmith, J ;
Levin, TN ;
Pepine, CJ ;
Schaeffer, JW ;
Smith, EE ;
Steward, DE ;
Theroux, P ;
Gibbons, RJ ;
Alpert, JS ;
Faxon, DP ;
Fuster, V ;
Gregoratos, G ;
Hiratzka, LF ;
Jacobs, AK ;
Smith, SC .
CIRCULATION, 2002, 106 (14) :1893-1900
[8]  
Butkiewicz Anna Maria, 2003, Kardiol Pol, V58, P449
[9]  
Cannon C P., 2005, Hurst's The Heart, V11th, P1243
[10]   Mean platelet volume in the patients with cardiac syndrome X [J].
Cay, S ;
Biyikoglu, F ;
Cihan, G ;
Korkmaz, S .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2005, 20 (03) :175-178