Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

被引：88

作者：

Dobre, Daniela ^{[1
]}

Borer, Jeffrey S. ^{[2
,3
]}

Fox, Kim ^{[4
]}

Swedberg, Karl ^{[5
]}

Adams, Kirkwood F. ^{[6
]}

Cleland, John G. F. ^{[7
]}

Cohen-Solal, Alain ^{[8
,9
]}

Gheorghiade, Mihai ^{[10
]}

Gueyffier, Francois ^{[11
]}

O'Connor, Christopher M. ^{[12
,13
]}

Fiuzat, Mona ^{[12
,13
]}

Patak, Athul ^{[14
,15
]}

Pina, Ileana L. ^{[16
]}

Rosano, Giuseppe ^{[17
]}

Sabbah, Hani N. ^{[18
]}

Tavazzi, Luigi ^{[19
]}

Zannad, Faiez ^{[1
,20
]}

机构：

[1] Univ Lorraine, INSERM, Ctr Clin Invest 9501, Inst Lorrain Coeur & Vaisseaux,CHU Nancy, Nancy, France

[2] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA

[3] Suny Downstate Med Ctr, New York, NY USA

[4] Univ London Imperial Coll Sci Technol & Med, NHLI, ICMS, Royal Brompton Hosp, London, England

[5] Univ Gothenburg, Dept Mol & Clin Med, Sahlgrenska Acad, Gothenburg, Sweden

[6] Univ N Carolina, Div Cardiol, Chapel Hill, NC USA

[7] Univ Hull, Hull York Med Sch, Kingston Upon Hull HU6 7RX, N Humberside, England

[8] Univ Paris 07, Dept Cardiol, Hop Lariboisiere, Paris, France

[9] Univ Paris 07, Res Med Unit INSERM U 942, Hop Lariboisiere, Paris, France

[10] Northwestern Univ, Ctr Cardiovasc Innovat, Feinberg Sch Med, Chicago, IL 60611 USA

[11] Hosp Civils Lyon, Lyon, France

[12] Duke Univ, Durham, NC USA

[13] Duke Clin Res Inst, Durham, NC USA

[14] Unite INSERM U 1048, Dept Clin Pharmacol, Toulouse, France

[15] Fac Med Toulouse, Toulouse, France

[16] Montefiore Med Ctr, Albert Einstein Coll Med, Div Cardiol, Bronx, NY 10467 USA

[17] IRCCS San Raffaele Roma, Cardiovasc Res Unit, Rome, Italy

[18] Henry Ford Hosp, Dept Med, Detroit, MI 48202 USA

[19] Maria Cecilia Hosp, GVM Care & Res, ES Hlth Sci Fdn, Cotignola, Italy

[20] Univ Lorraine, INSERM U961, Nancy, France

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2014年 / 16卷 / 01期

关键词：

Heart rate; Heart rate-lowering drugs; Beta-blockers; Ivabradine; Digoxin; Amiodarone; Verapamil; Chronic heart failure; SYSTOLIC DYSFUNCTION BEAUTIFUL; CORONARY-ARTERY-DISEASE; ATRIAL-FIBRILLATION; RATE REDUCTION; CLINICAL-OUTCOMES; CARDIOVASCULAR OUTCOMES; INCREASED MORTALITY; ELDERLY-PATIENTS; RISK-FACTOR; DIGOXIN;

D O I：

10.1093/eurjhf/hft129

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.

引用

页码：76 / 85

页数：10

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