Diastereodivergent De-epimerization in Catalytic Asymmetric Allylic Alkylation

被引：59

作者：

Audisio, Davide ^{[1
]}

Luparia, Marco ^{[1
]}

Oliveira, Maria Teresa ^{[1
]}

Kluett, Dina ^{[1
]}

Maulide, Nuno ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 29期

基金：

欧洲研究理事会;

关键词：

de-epimerization; diastereodivergence; enantioselectivity; palladium; reaction mechanisms; TRANSFORMATION; LIGANDS; PHOSPHORAMIDITES; CLASSIFICATION; NUCLEOPHILES; RACEMIZATION; ALLYLATION; RESOLUTION; VERSATILE; 2-PYRONE;

D O I：

10.1002/anie.201202853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diastereomers made to order: In an unprecedented ligand-controlled process a racemic mixture of four stereoisomers can be converted with high selectivity into each one of the diastereomers of the product, at will (see scheme). The mechanism of this deracemization of epimers, that is, a de-epimerization, was also studied. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7314 / 7317

页数：4

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