Health benefits of high-density lipoproteins in preventing cardiovascular diseases

被引：50

作者：

Berrougui, Hicham ^{[1
,2
]}

Momo, Claudia N. ^{[1
]}

Khalil, Abdelouahed ^{[1
]}

机构：

[1] Univ Sherbrooke, Res Ctr Aging, Geriatr Inst, Sherbrooke, PQ J1H 4C4, Canada

[2] Univ Sultan Moulay Slimane, Dept Biol, Beni Mellal, Morocco

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2012年 / 6卷 / 06期

基金：

加拿大健康研究院;

关键词：

Atherogenesis; Cardiovascular diseases; Cholesterol efflux; HDL; Paraoxonase; 1; Reverse cholesterol transport; APOLIPOPROTEIN-A-I; REVERSE CHOLESTEROL TRANSPORT; CORONARY-HEART-DISEASE; SCAVENGER RECEPTOR BI; MEMBRANE LIPID RAFTS; PRE-BETA-HDL; CELLULAR CHOLESTEROL; SR-BI; PHOSPHOLIPID-COMPOSITION; PARAOXONASE ACTIVITY;

D O I：

10.1016/j.jacl.2012.04.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL is a more desirable target than simply increasing HDL-cholesterol levels. The best known antiatherogenic function of HDL particles relates to their ability to promote reverse cholesterol transport from peripheral cells. However, HDL also possesses antioxidant, anti-inflammatory, and antithrombotic effects. This review focuses on the state of knowledge regarding assays of HDL heterogeneity and function and their relationship to cardiovascular diseases. (C) 2012 National Lipid Association. All rights reserved.

引用

页码：524 / 533

页数：10

共 80 条

[1]

The roles of different pathways in the release of cholesterol from macrophages [J].

Adorni, Maria Pia ;

Zimetti, Francesca ;

Billheimer, Jeffrey T. ;

Wang, Nan ;

Rader, Daniel J. ;

Phillips, Michael C. ;

Rothblat, George H. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (11) :2453-2462

[2]

On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: Physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes [J].

Ahmed, SN ;

Brown, DA ;

London, E .

BIOCHEMISTRY, 1997, 36 (36) :10944-10953

[3]

The paradox of dysfunctional high-density lipoprotein [J].

Ansell, Benjamin J. ;

Fonarow, Gregg C. ;

Fogelman, Alan M. .

CURRENT OPINION IN LIPIDOLOGY, 2007, 18 (04) :427-434

[4]

Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment [J].

Ansell, BJ ;

Navab, M ;

Hama, S ;

Kamranpour, N ;

Fonarow, G ;

Hough, G ;

Rahmani, S ;

Mottahedeh, R ;

Dave, R ;

Reddy, ST ;

Fogelman, AM .

CIRCULATION, 2003, 108 (22) :2751-2756

[5]

HDL cholesterol and protective factors in atherosclerosis [J].

Assmann, G ;

Gotto, AM .

CIRCULATION, 2004, 109 (23) :8-14

[6]

Baker PW, 2000, J LIPID RES, V41, P1261

[7]

Distribution spectrum of paraoxonase activity in HDL fractions [J].

Bergmeier, C ;

Siekmeier, R ;

Gross, W .

CLINICAL CHEMISTRY, 2004, 50 (12) :2309-2315

[8]

Purified human paraoxonase-1 interacts with plasma membrane lipid rafts and mediates cholesterol efflux from macrophages [J].

Berrougui, Hicham ;

Loued, Soumaya ;

Khalil, Abdelouahed .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 52 (08) :1372-1381

[9]

Age-Associated Decrease of High-Density Lipoprotein-Mediated Reverse Cholesterol Transport Activity [J].

Berrougui, Hicham ;

Khalil, Abdelouahed .

REJUVENATION RESEARCH, 2009, 12 (02) :117-126

[10]

Brufau G, 2011, ARTERIOSCLER THROMB, V31, P1726

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