A dynamic zone defines interneuron remodeling in the adult neocortex

被引：67

作者：

Lee, Wei-Chung Allen ^{[1
,2
]}

Chen, Jerry L. ^{[1
,3
]}

Huang, Hayden ^{[4
]}

Leslie, Jennifer H. ^{[1
,3
]}

Amitai, Yael ^{[2
,5
]}

So, Peter T. ^{[4
]}

Nedivi, Elly ^{[1
,2
,3
]}

机构：

[1] MIT, Picower Inst Learning & Memory, Cambridge, MA 02139 USA

[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

[4] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[5] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Physiol, IL-84105 Beer Sheva, Israel

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 50期

关键词：

dendrite; inhibitory; plasticity; two-photon microscopy; visual cortex;

D O I：

10.1073/pnas.0810149105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The contribution of structural remodeling to long-term adult brain plasticity is unclear. Here, we investigate features of GABAergic interneuron dendrite dynamics and extract clues regarding its potential role in cortical function and circuit plasticity. We show that remodeling interneurons are contained within a "dynamic zone" corresponding to a superficial strip of layers 2/3, and remodeling dendrites respect the lower border of this zone. Remodeling occurs primarily at the periphery of dendritic fields with addition and retraction of new branch tips. We further show that dendrite remodeling is not intrinsic to a specific interneuron class. These data suggest that interneuron remodeling is not a feature predetermined by genetic lineage, but rather, it is imposed by cortical laminar circuitry. Our findings are consistent with dynamic GABAergic modulation of feedforward and recurrent connections in response to top-down feedback and suggest a structural component to functional plasticity of supragranular neocortical laminae.

引用

页码：19968 / 19973

页数：6

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