Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats

被引：78

作者：

Parker, LA ^{[1
]}

Mechoulam, R

Schlievert, C

机构：

[1] Wilfrid Laurier Univ, Dept Psychol, Waterloo, ON N2L 3C5, Canada

[2] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

来源：

NEUROREPORT | 2002年 / 13卷 / 05期

关键词：

cannabidiol; cannabinoid; emesis; marijuana; nausea; taste avoidance; taste reactivity;

D O I：

10.1097/00001756-200204160-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats display conditioned rejection reactions during an oral infusion of a flavor previously paired with an emetic drug; considerable evidence indicates that these rejection reactions reflect nausea. Here we report that cannabidiol, a major non-psychoactive cannabinoid found in marijuana and its synthetic dimethylheptyl homolog interfere with nausea elicited by lithium chloride and with conditioned nausea elicited by a flavor paired with lithium chloride. These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea. NeuroReport 13:567-570 (C) 2002 Lippincott Williams Wilkins.

引用

页码：567 / 570

页数：4

共 20 条

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