GG: A domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases

被引：41

作者：

Guo, JH

Cheng, HP

Zhao, SY

Yu, L

机构：

[1] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA

[2] Fudan Univ, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

FEBS LETTERS | 2006年 / 580卷 / 02期

关键词：

GG domain; LTF apparatus; muscle-eye-brain disease; non-syndromic hearing loss; Gp35; POMGnT1; KIAA1199; FAM3; superfamily;

D O I：

10.1016/j.febslet.2005.12.076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we report the identification of a novel domain-GG (domain in KIAA1199, FAM3, POMGnT1 and Tmem2 proteins, with two well-conserved glycine residues), present in eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C and FAM3D), POMGnT1 (protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase), TEM2 proteins as well as phage gp35 proteins. GG domain has been revealed to be implicated in muscle-eye-brain disease and non-syndromic hearing loss. The presence of GG domain in Bacteriophage gp35 hinge connector of long tail fiber might reflect the horizontal gene transfer from organisms. And we proposed that GG domain might function as important structural element in phage LTF. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：581 / 584

页数：4

共 15 条

[1] Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss [J].