mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD induction, in the dentate gyrus in vitro

被引:67
作者
Huang, LQ [1 ]
Rowan, MJ [1 ]
Anwyl, R [1 ]
机构
[1] UNIV DUBLIN TRINITY COLL,DEPT PHARMACOL & EXPT THERAPEUT,DUBLIN 2,IRELAND
基金
英国惠康基金;
关键词
DCG-IV; hippocampus; MCCG; mGluR;
D O I
10.1097/00001756-199702100-00022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE effects of the metabotropic glutamate receptor (mGluR) group II agonist (2S,1'R,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) and the antagonist 2S,1S',2S'-2-methyl-2-(2'-carboxycyclopropyl)glycine (MCCG) on the induction of long-term potentiation (LTP) and long-term depression (LTD) of the field excitatory postsynaptic potential (epsp) in the dentate gyrus of the rat hippocampus were investigated in vitro. In control media, high frequency stimulation (I-IFS) consisting of a series of trains of stimuli at 200 Hz induced LTP, and low frequency stimulation (LFS) consisting of 900 stimuli at 1 Hz induced LTD. DCG-IV (50 nM) strongly inhibited the induction of LTP. The block of LTP induction was not caused by a frequency-dependent inhibition of the epsp during HFS, as the epsps evoked during HFS were not altered by DCG-IV. MCCG (500 mu M) did not inhibit the induction of LTP, but did prevent the block of LTP by DCG-IV. MCCG (500 mu M) strongly inhibited the induction of LTD. DCG-IV (50 nM) did not inhibit LTD induction.
引用
收藏
页码:687 / 693
页数:7
相关论文
共 23 条
[1]   INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS [J].
BASHIR, ZI ;
BORTOLOTTO, ZA ;
DAVIES, CH ;
BERRETTA, N ;
IRVING, AJ ;
SEAL, AJ ;
HENLEY, JM ;
JANE, DE ;
WATKINS, JC ;
COLLINGRIDGE, GL .
NATURE, 1993, 363 (6427) :347-350
[2]   AN INVESTIGATION OF DEPOTENTIATION OF LONG-TERM POTENTIATION IN THE CA1 REGION OF THE HIPPOCAMPUS [J].
BASHIR, ZI ;
COLLINGRIDGE, GL .
EXPERIMENTAL BRAIN RESEARCH, 1994, 100 (03) :437-443
[3]   L-2-AMINO-3-PHOSPHONOPROPIONATE BLOCKS LATE SYNAPTIC LONG-TERM POTENTIATION [J].
BEHNISCH, T ;
FJODOROW, K ;
REYMANN, KG .
NEUROREPORT, 1991, 2 (07) :386-388
[4]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[5]   Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region [J].
Blitzer, RD ;
Wong, T ;
Nouranifar, R ;
Iyengar, R ;
Landau, EM .
NEURON, 1995, 15 (06) :1403-1414
[6]   POSTSYNAPTIC INDUCTION AND PRESYNAPTIC EXPRESSION OF HIPPOCAMPAL LONG-TERM DEPRESSION [J].
BOLSHAKOV, VY ;
SIEGELBAUM, SA .
SCIENCE, 1994, 264 (5162) :1148-1152
[7]   CHARACTERIZATION OF LTP INDUCED BY THE ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS IN AREA CA1 OF THE HIPPOCAMPUS [J].
BORTOLOTTO, ZA ;
COLLINGRIDGE, GL .
NEUROPHARMACOLOGY, 1993, 32 (01) :1-9
[8]   METABOTROPIC GLUTAMATE-RECEPTOR AGONISTS REDUCE PAIRED-PULSE DEPRESSION IN THE DENTATE GYRUS OF THE RAT IN-VITRO [J].
BROWN, RE ;
REYMANN, KG .
NEUROSCIENCE LETTERS, 1995, 196 (1-2) :17-20
[9]   Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices [J].
Bushell, TJ ;
Jane, DE ;
Tse, HW ;
Watkins, JC ;
Garthwaite, J ;
Collingridge, GL .
BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (07) :1457-1462
[10]   EFFECTS OF CAMP SIMULATE A LATE-STAGE OF LTP IN HIPPOCAMPAL CA1 NEURONS [J].
FREY, U ;
HUANG, YY ;
KANDEL, ER .
SCIENCE, 1993, 260 (5114) :1661-1664