Immunological tolerance: Danger - Pathogen on the premises!

被引：77

作者：

Janeway, CA ^{[1
]}

Goodnow, CC ^{[1
]}

Medzhitov, R ^{[1
]}

机构：

[1] STANFORD UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305

来源：

CURRENT BIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0960-9822(02)00531-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent results show that immune responses can be induced in neonatal mice, Do they really refute the traditional view that the ability to discriminate between 'self' and 'non-self' is a fundamental property of the immune system?

引用

页码：519 / 522

页数：4

共 20 条

[1] THE CD40 ANTIGEN AND ITS LIGAND [J].

BANCHEREAU, J ;

BAZAN, F ;

BLANCHARD, D ;

BRIERE, F ;

GALIZZI, JP ;

VANKOOTEN, C ;

LIU, YJ ;

ROUSSET, F ;

SAELAND, S .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :881-922

[2] ACTIVELY ACQUIRED TOLERANCE OF FOREIGN CELLS [J].

BILLINGHAM, RE ;

BRENT, L ;

MEDAWAR, PB .

NATURE, 1953, 172 (4379) :603-606

[3] A THEORY OF SELF-NONSELF DISCRIMINATION [J].

BRETSCHER, P ;

COHN, M .

SCIENCE, 1970, 169 (3950) :1042-+

[4]

BURNET FM, 1959, CLONAL SELECTION THE

[5] Induction of T(H)1 and T(H)2 immunity in neonatal mice [J].

Forsthuber, T ;

Yip, HC ;

Lehmann, PV .

SCIENCE, 1996, 271 (5256) :1728-1730

[6] Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires [J].

Goodnow, CC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2264-2271

[7] SIGNALS AND SIGNS FOR LYMPHOCYTE-RESPONSES [J].

JANEWAY, CA ;

BOTTOMLY, K .

CELL, 1994, 76 (02) :275-285

[8] THE IMMUNE-SYSTEM EVOLVED TO DISCRIMINATE INFECTIOUS NONSELF FROM NONINFECTIOUS SELF [J].

JANEWAY, CA .

IMMUNOLOGY TODAY, 1992, 13 (01) :11-16

[9]

JANEWAY CA, 1989, COLD SPRING HARB SYM, V54, P1

[10]

Johnson G., 1996, NY TIMES, p[C, C]

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