The effects of IL-6 on CD4 T cell responses

被引：408

作者：

Dienz, Oliver ^{[1
]}

Rincon, Mercedes ^{[1
]}

机构：

[1] Univ Vermont, Dept Med, Immunobiol program, Burlington, VT 05405 USA

来源：

CLINICAL IMMUNOLOGY | 2009年 / 130卷 / 01期

关键词：

IL-6; IL-6R; CD4 T cell differentiation T helper response; Th1/Th2/Th17; IL-21; Autoimmune disease; Allergic airway inflammation; GROWTH-FACTOR-BETA; SOLUBLE INTERLEUKIN-6 RECEPTOR; CUTTING EDGE; TGF-BETA; SIGNAL TRANSDUCER; TH17; CELLS; DIFFERENTIATION; TRANSCRIPTION; CYTOKINE; NAIVE;

D O I：

10.1016/j.clim.2008.08.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines have tong been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our tab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：27 / 33

页数：7

共 61 条

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