Excavatolides U-Z, new briarane diterpenes from the gorgonian Briareum excavatum

被引：44

作者：

Sheu, JH ^{[1
]}

Sung, PJ

Su, JH

Wang, GH

Duh, CY

Shen, YC

Chiang, MY

Chen, IT

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 10期

关键词：

D O I：

10.1021/np990302i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U-Z (1-6). The structures and relative stereochemistry of metabolites 1-6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.

引用

页码：1415 / 1420

页数：6

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