Cyclin G: A regulator of the p53-Mdm2 network

被引：36

作者：

Chen, XB ^{[1
]}

机构：

[1] Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA

来源：

DEVELOPMENTAL CELL | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1534-5807(02)00182-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

A recent study published in the April issue of Molecular Cell has shown that cyclin G, a p53 target, is a regulatory component of the active PP2A holoenzyme, which activates Mdm2 through dephosphorylation. These findings suggest that cyclin G is a key regulator of the p53-Mdm2 network.

引用

收藏

页码：518 / 519

页数：2

相关论文

共 10 条

[1]

GAK: A cyclin G associated kinase contains a tensin/auxilin-like domain [J].

Kanaoka, Y ;

Kimura, SH ;

Okazaki, I ;

Ikeda, M ;

Nojima, H .

FEBS LETTERS, 1997, 402 (01) :73-80

[2]

Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery [J].

Kimura, SH ;

Ikawa, M ;

Ito, A ;

Okabe, M ;

Nojima, H .

ONCOGENE, 2001, 20 (25) :3290-3300

[3]

p53: Puzzle and paradigm [J].

Ko, LJ ;

Prives, C .

GENES & DEVELOPMENT, 1996, 10 (09) :1054-1072

[4]

The p53 and Mdm2 families in cancer [J].

Michael, D ;

Oren, M .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (01) :53-59

[5]

Morita N, 1996, J NEUROSCI, V16, P5961

[6]

CYCLIN-G IS A TRANSCRIPTIONAL TARGET OF THE P53 TUMOR-SUPPRESSOR PROTEIN [J].

OKAMOTO, K ;

BEACH, D .

EMBO JOURNAL, 1994, 13 (20) :4816-4822

[7]

A role of cyclin G in the process of apoptosis [J].

Okamoto, K ;

Prives, C .

ONCOGENE, 1999, 18 (32) :4606-4615

[8]

Okamoto K, 1996, MOL CELL BIOL, V16, P6593

[9]

Cyclin G recruits PP2A to dephosphorylate Mdm2 [J].

Okamoto, K ;

Li, HY ;

Jensen, MR ;

Zhang, TT ;

Taya, Y ;

Thorgeirsson, SS ;

Prives, C .

MOLECULAR CELL, 2002, 9 (04) :761-771

[10]

SKOTZKO M, 1995, CANCER RES, V55, P5493