Developmental regulation of DNA replication timing at the human β globin locus

被引：74

作者：

Simon, I

Tenzen, T

Mostoslavsky, R

Fibach, E

Lande, L

Milot, E

Gribnau, J

Grosveld, F

Fraser, P

Cedar, H ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Med, Dept Cellular Biochem, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Sch Med, Dept Hematol, IL-91120 Jerusalem, Israel

[3] Natl Inst Genet, Dept Evolutionary Genet, Mishima, Shizuoka 4118540, Japan

[4] Erasmus Univ, MGC Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

来源：

EMBO JOURNAL | 2001年 / 20卷 / 21期

关键词：

beta globin; LCR; replication timing;

D O I：

10.1093/emboj/20.21.6150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human beta globin locus replicates late in most cell types, but becomes early replicating in erythroid cells. Using FISH to map DNA replication timing around the endogenous beta globin locus and by applying a genetic approach in transgenic mice, we have demonstrated that both the late and early replication states are controlled by regulatory elements within the locus control region. These results also show that the pattern of replication timing is set up by mechanisms that work independently of gene transcription.

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收藏

页码：6150 / 6157

页数：8

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