Structure and function of the epidermis related to barrier properties

被引：333

作者：

Baroni, Adone ^{[1
]}

Buommino, Elisabetta ^{[2
]}

De Gregorio, Vincenza ^{[2
]}

Ruocco, Eleonora ^{[1
]}

Ruocco, Vincenzo ^{[1
]}

Wolf, Ronni ^{[3
,4
]}

机构：

[1] Univ Naples 2, Dept Dermatol, I-80131 Naples, Italy

[2] Univ Naples 2, Dept Expt Med, Microbiol & Clin Microbiol Sect, I-80138 Naples, Italy

[3] Kaplan Med Ctr, Dermatol Unit, IL-76100 Rehovot, Israel

[4] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91010 Jerusalem, Israel

来源：

CLINICS IN DERMATOLOGY | 2012年 / 30卷 / 03期

关键词：

ANTIMICROBIAL PEPTIDES; BETA-DEFENSINS; STEM-CELLS; SKIN; INNATE; CATHELICIDINS; ACTIVATORS; INFECTION; IMMUNITY; CALCIUM;

D O I：

10.1016/j.clindermatol.2011.08.007

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The most important function of the skin is the formation of a barrier between the "inside" and the "outside" of the organism, which prevents invasion of pathogens and fends off chemical assaults as well as the unregulated loss of water and solutes. The physical barrier is mainly localized in the stratum corneum, which consists of protein-enriched cells and lipid-enriched intercellular domains. Any modifications in epidermal differentiation and lipid composition results in altered barrier function, a central event in various skin alterations and diseases. This contribution presents a brief description of the structure of the skin, paying attention to the most important components responsible for skin barrier function. (C) 2012 Published by Elsevier Inc.

引用

页码：257 / 262

页数：6

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[1] Epidermal stem cells of the skin [J].