Neurophysiological markers of attention distinguish bipolar disorder and unipolar depression

被引:7
作者
Barreiros, Ana R. [1 ]
Breukelaar, Isabella A. [1 ]
Chen, Wenting [1 ]
Erlinger, May [1 ]
Antees, Cassandra [1 ]
Medway, Meredith [1 ]
Boyce, Philip [2 ]
Hazell, Philip [2 ]
Williams, Leanne M. [1 ,3 ,4 ]
Malhi, Gin S. [2 ,5 ]
Harris, Anthony W. F. [1 ,2 ]
Korgaonkar, Mayuresh S. [1 ,2 ]
机构
[1] Univ Sydney, Westmead Inst Med Res, Brain Dynam Ctr, Westmead, NSW, Australia
[2] Univ Sydney, Sydney Med Sch, Discipline Psychiat, Sydney, NSW, Australia
[3] Stanford Univ, Psychiat & Behav Sci, Stanford, CA 94305 USA
[4] Sierra Pacific Mental Illness Res Educ & Clin Ctr, Palo Alto, CA USA
[5] Royal North Shore Hosp, Dept Psychiat, CADE Clin, Sydney, NSW, Australia
基金
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词
Bipolar disorder; Major depressive disorder; Biomarker; Event-related potentials; P300; Attention; EVENT-RELATED POTENTIALS; P300; COMPONENT; 1ST EPISODE; EUTHYMIC PATIENTS; RATING-SCALE; ILLNESS; METAANALYSIS; DIAGNOSIS; SYMPTOMS; VALIDITY;
D O I
10.1016/j.jad.2020.05.048
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Background: Attentional deficits are common in both symptomatic and symptom-remitted patients with bipolar disorder (BP) and major depressive disorder (MDD). However, whether the level of neurocognitive impairment in attentional processing is different between these two disorders, or not, is still unclear. Thus, we investigated the P300 event-related potential component as a biomarker of cognitive dysfunction to differentiate BP and MDD. Methods: Twenty-three age and gender matched BP, 20 MDD and 23 healthy controls (HC) were part of a discovery cohort to identify neurophysiological differences between groups and build a classification model of these disorders. The replication of this model was then tested in an independent second cohort of 17 BP, 19 MDD and 19 HC. All participants were symptom-remitted for at least two weeks. We compared neural responses to target stimuli during an auditory oddball task, computing peak amplitude and latency of the P300 component extracted from the midline centro-parietal electrode. Results: BP had significantly smaller P300 amplitudes compared to both MDD and HC, whereas there were no differences between MDD and HC. The differences between groups were replicated in the second cohort, however the accuracy level of the classification model was only 53.5%. Limitations: Small sample sizes may have led to low accuracy levels of the classification model. Conclusion: Specific neural mechanisms of attention and context updating seem not to recover with symptom remission in BP. These findings contribute to the detection of a potential electrophysiological marker for BP, which may allow its differentiation from unipolar major depressive disorder.
引用
收藏
页码:411 / 419
页数:9
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