Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication

被引：98

作者：

Mossman, KL ^{[1
]}

Smiley, JR ^{[1
]}

机构：

[1] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 04期

关键词：

D O I：

10.1128/JVI.76.4.1995-1998.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interferon inhibits virus replication through multiple mechanisms. Here we show that herpes simplex virus proteins ICP0 and ICP34.5 overcome interferon-induced barriers to viral transcription and translation, respectively. These cytokine-induced antiviral mechanisms are differentially expressed in established cell lines: U2OS cells do not mount the IFN-induced mechanism targeted by ICP0, and Vero cells may be defective for the mechanism targeted by ICP34.5.

引用

页码：1995 / 1998

页数：4

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